ConclusionsĬrs < 48 ml/cmH 2O was associated with ICU mortality, while DP was linearly associated with mortality. Multivariable analysis confirmed these findings. The logistic regression analysis showed that: (1) Crs was not linearly associated with ICU mortality ( p value for nonlinearity = 0.01), with a greater risk of death for values < 48 ml/cmH 2O (2) the association between DP and ICU mortality was linear ( p value for nonlinearity = 0.68), and increasing DP from 10 to 14 cmH 2O caused significant higher odds of in-ICU death (OR 1.45, 95% CI 1.06–1.99) (3) VT/kg IBW was not associated with a significant increase of the risk of death (OR 0.92, 95% CI 0.55–1.52). ResultsĪ total of 704 COVID-19 patients were screened and 241 enrolled. Crs, DP and VT/kg IBW were collected in sedated, paralyzed and supine patients. Only patients fulfilling ARDS criteria and with complete records of Crs, DP and VT/kg IBW within the 1st day of controlled mechanical ventilation were included. All consecutive COVID-19 adult patients admitted to 25 ICUs belonging to the COVID-19 VENETO ICU network (February 28th–April 28th, 2020), who received controlled mechanical ventilation, were screened. We aim ascertaining whether respiratory system static compliance (Crs), driving pressure (DP), and tidal volume normalized for ideal body weight (VT/kg IBW) at the 1st day of controlled mechanical ventilation are associated with intensive care unit (ICU) mortality in COVID-19 ARDS. ![]() Pathophysiological features of coronavirus disease 2019-associated acute respiratory distress syndrome (COVID-19 ARDS) were indicated to be somewhat different from those described in nonCOVID-19 ARDS, because of relatively preserved compliance of the respiratory system despite marked hypoxemia.
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